Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.
Identifieur interne : 000224 ( Main/Exploration ); précédent : 000223; suivant : 000225Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.
Auteurs : Cláudia Saraiva [Portugal] ; Catarina Praça [France] ; Raquel Ferreira [Portugal] ; Tiago Santos [Portugal] ; Lino Ferreira [Portugal] ; Liliana Bernardino [Portugal]Source :
- Journal of controlled release : official journal of the Controlled Release Society [ 1873-4995 ] ; 2016.
Abstract
The blood-brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain homeostasis as well as ion and molecule movement. Failure in maintaining any of these components results in the breakdown of this specialized multicellular structure and consequently promotes neuroinflammation and neurodegeneration. In several high incidence pathologies such as stroke, Alzheimer's (AD) and Parkinson's disease (PD) the BBB is impaired. However, even a damaged and more permeable BBB can pose serious challenges to drug delivery into the brain. The use of nanoparticle (NP) formulations able to encapsulate molecules with therapeutic value, while targeting specific transport processes in the brain vasculature, may enhance drug transport through the BBB in neurodegenerative/ischemic disorders and target relevant regions in the brain for regenerative processes. In this review, we will discuss BBB composition and characteristics and how these features are altered in pathology, namely in stroke, AD and PD. Additionally, factors influencing an efficient intravenous delivery of polymeric and inorganic NPs into the brain as well as NP-related delivery systems with the most promising functional outcomes will also be discussed.
DOI: 10.1016/j.jconrel.2016.05.044
PubMed: 27208862
Affiliations:
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Electronic address: libernardino@gmail.com.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã</wicri:regionArea><wicri:noRegion>6200-506 Covilhã</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of controlled release : official journal of the Controlled Release Society</title><idno type="eISSN">1873-4995</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The blood-brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain homeostasis as well as ion and molecule movement. Failure in maintaining any of these components results in the breakdown of this specialized multicellular structure and consequently promotes neuroinflammation and neurodegeneration. In several high incidence pathologies such as stroke, Alzheimer's (AD) and Parkinson's disease (PD) the BBB is impaired. However, even a damaged and more permeable BBB can pose serious challenges to drug delivery into the brain. The use of nanoparticle (NP) formulations able to encapsulate molecules with therapeutic value, while targeting specific transport processes in the brain vasculature, may enhance drug transport through the BBB in neurodegenerative/ischemic disorders and target relevant regions in the brain for regenerative processes. In this review, we will discuss BBB composition and characteristics and how these features are altered in pathology, namely in stroke, AD and PD. Additionally, factors influencing an efficient intravenous delivery of polymeric and inorganic NPs into the brain as well as NP-related delivery systems with the most promising functional outcomes will also be discussed.</div></front></TEI><affiliations><list><country><li>France</li><li>Portugal</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lens (Pas-de-Calais)</li></settlement></list><tree><country name="Portugal"><noRegion><name sortKey="Saraiva, Claudia" sort="Saraiva, Claudia" uniqKey="Saraiva C" first="Cláudia" last="Saraiva">Cláudia Saraiva</name></noRegion><name sortKey="Bernardino, Liliana" sort="Bernardino, Liliana" uniqKey="Bernardino L" first="Liliana" last="Bernardino">Liliana Bernardino</name><name sortKey="Ferreira, Lino" sort="Ferreira, Lino" uniqKey="Ferreira L" first="Lino" last="Ferreira">Lino Ferreira</name><name sortKey="Ferreira, Raquel" sort="Ferreira, Raquel" uniqKey="Ferreira R" first="Raquel" last="Ferreira">Raquel Ferreira</name><name sortKey="Santos, Tiago" sort="Santos, Tiago" uniqKey="Santos T" first="Tiago" last="Santos">Tiago Santos</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Praca, Catarina" sort="Praca, Catarina" uniqKey="Praca C" first="Catarina" last="Praça">Catarina Praça</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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